Abstract |
The aim of this study was to assess oxidative stress in pregnant women infected with cytomegalovirus on the basis of 3-nitrotyrosine levels in amniotic fluid (AF). The 3-nitrotyrosine (3-NT) level in AF was measured using the competitive ELISA method. The study groups were as follows: group I consisted of women with IgM and/or IgA; group II were women with only IgG anti-CMV antibodies and group III were seronegative women, used as the control group. Age, gestational age and socioeconomic status were also assessed. The average level of 3-nitrotyrosine in group II and the control group was similar: 53.14 nM 3-NT and 49.78 nM 3-NT, respectively. However, in group I, the lowest level 3-NT in AF was observed - 39.17 nM 3-NT and statistical analysis showed significant differences in levels of 3-NT between group I and the control group (p < 0.01). We conclude that significantly lower levels of 3-nitrotyrosine in pregnant women with CMV infection may indicate an increase in the antioxidant defence mechanisms in these patients.
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Authors | Z Gaj, J Wilczynski, A Nowakowska-Glab, F Boakye-Agyeman, E Paradowska, Z J Lesnikowski, D Nowakowska |
Journal | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
(J Obstet Gynaecol)
Vol. 34
Issue 3
Pg. 251-4
(Apr 2014)
ISSN: 1364-6893 [Electronic] England |
PMID | 24483707
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Amniotic Fluid
(metabolism)
- Case-Control Studies
- Cytomegalovirus Infections
(metabolism)
- Female
- Humans
- Oxidative Stress
- Pregnancy
- Pregnancy Complications, Infectious
(metabolism)
- Tyrosine
(analogs & derivatives, metabolism)
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