45Ca uptake and the actions of Bay K 8644 on aortic strips from rabbits with perinephritis hypertension.

Abstract

Uptake of 45Ca was measured in rings of thoracic aorta from rabbits with hypertension, induced by cellophane perinephritis (Page hypertension: one-kidney, one wrap). Basal 45Ca uptake was increased significantly in the hypertensive group (sham: 100 +/- 3, hypertensive: 133 +/- 11 nmol/g wet weight, n = 6). 45Ca uptake was increased by KCl (30 mmol/l), norepinephrine (50 nmol/l) and Bay K 8644 (14 or 56 nmol/l) by the following amounts: 152, 15, 28 and 36%, respectively. Stimulated 45Ca uptake was less in hypertensive animals for all agonists. The augmenting effect of Bay K 8644 on 45Ca uptake, stimulated by norepinephrine or by KCl, was also reduced in hypertension. It is concluded that in hypertension there are alterations in the Ca regulatory process and in the properties of the Ca channel in arterial muscle.

• Authors: Y Dong, R M Wadsworth
• Journal: Journal of hypertension (J Hypertens) Vol. 5 Issue 6 Pg. 711-4 (Dec 1987) ISSN: 0263-6352 [Print] England
• PMID: 2448370 (Publication Type: Journal Article)

Chemical References

• Calcium Radioisotopes
• Potassium Chloride
• 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
• Calcium
• Norepinephrine

Topics

• 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester (pharmacology)
• Animals
• Aorta, Thoracic (drug effects, metabolism)
• Arteries (drug effects, metabolism)
• Calcium (metabolism)
• Calcium Radioisotopes
• Drug Interactions
• Hypertension, Renal (metabolism)
• In Vitro Techniques
• Nephritis (complications)
• Norepinephrine (pharmacology)
• Potassium Chloride (pharmacology)
• Rabbits