Abstract | PURPOSE: Large epidemiologic studies about the relationship between benzo[a]pyrene (B[a]P) and hepatocellular carcinoma (HCC) have been limited. B[a]P diol epoxide ( BPDE) is a highly reactive metabolite of B[a]P that binds covalently to form DNA adducts. We evaluated the interaction between B[a]P exposure with other risk factors in HCC, in a case-control study of 345 HCC and 961 healthy controls. METHODS: Concentration of BPDE-DNA adducts in blood was determined by enzyme-linked immunosorbent assay. The interaction between BPDE-DNA adducts and other risk factors on HCC were evaluated by multivariate logistic regression analysis. RESULTS: Mean concentration of BPDE-DNA adducts in blood of cases was significantly higher than that of the controls. The risk of HCC increased with elevated concentration of BPDE-DNA adducts (x(2) = 203.57, Ptrend < .001) and the odds ratio was 7.44 (95% confidence interval, 5.29-10.45) for the first versus fourth quartile of adduct levels. The relative excess risk due to interaction between BPDE-DNA adducts and hepatitis B virus surface antigen and drinking was 34.71 and 54.92, and the attributable proportion due to interaction was 41.53% and 75.59%, respectively. CONCLUSIONS: The high level of BPDE-DNA adducts in blood is associated with HCC and that environmental exposure to B[a]P may increase the risk of HCC, especially among drinkers and populations with hepatitis B virus infection.
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Authors | Yanhua Su, Benhua Zhao, Fei Guo, Zhao Bin, Yue Yang, Sheng Liu, Yaofeng Han, Jianjun Niu, Xiayi Ke, Ning Wang, Xuesi Geng, Changnan Jin, Yichen Dai, Yuanyuan Lin |
Journal | Annals of epidemiology
(Ann Epidemiol)
Vol. 24
Issue 2
Pg. 98-103
(Feb 2014)
ISSN: 1873-2585 [Electronic] United States |
PMID | 24480391
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Carcinogens
- DNA Adducts
- Environmental Pollutants
- Benzo(a)pyrene
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Topics |
- Adult
- Aged
- Benzo(a)pyrene
(analysis, metabolism)
- Carcinogens
(analysis, metabolism)
- Carcinoma, Hepatocellular
(blood, genetics)
- Case-Control Studies
- China
- DNA Adducts
- Environmental Pollutants
(adverse effects)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Liver Neoplasms
(blood, genetics)
- Male
- Middle Aged
- Multivariate Analysis
- Regression Analysis
- Risk Factors
- Socioeconomic Factors
- Surveys and Questionnaires
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