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Interaction of benzo[a]pyrene with other risk factors in hepatocellular carcinoma: a case-control study in Xiamen, China.

AbstractPURPOSE:
Large epidemiologic studies about the relationship between benzo[a]pyrene (B[a]P) and hepatocellular carcinoma (HCC) have been limited. B[a]P diol epoxide (BPDE) is a highly reactive metabolite of B[a]P that binds covalently to form DNA adducts. We evaluated the interaction between B[a]P exposure with other risk factors in HCC, in a case-control study of 345 HCC and 961 healthy controls.
METHODS:
Concentration of BPDE-DNA adducts in blood was determined by enzyme-linked immunosorbent assay. The interaction between BPDE-DNA adducts and other risk factors on HCC were evaluated by multivariate logistic regression analysis.
RESULTS:
Mean concentration of BPDE-DNA adducts in blood of cases was significantly higher than that of the controls. The risk of HCC increased with elevated concentration of BPDE-DNA adducts (x(2) = 203.57, Ptrend < .001) and the odds ratio was 7.44 (95% confidence interval, 5.29-10.45) for the first versus fourth quartile of adduct levels. The relative excess risk due to interaction between BPDE-DNA adducts and hepatitis B virus surface antigen and drinking was 34.71 and 54.92, and the attributable proportion due to interaction was 41.53% and 75.59%, respectively.
CONCLUSIONS:
The high level of BPDE-DNA adducts in blood is associated with HCC and that environmental exposure to B[a]P may increase the risk of HCC, especially among drinkers and populations with hepatitis B virus infection.
AuthorsYanhua Su, Benhua Zhao, Fei Guo, Zhao Bin, Yue Yang, Sheng Liu, Yaofeng Han, Jianjun Niu, Xiayi Ke, Ning Wang, Xuesi Geng, Changnan Jin, Yichen Dai, Yuanyuan Lin
JournalAnnals of epidemiology (Ann Epidemiol) Vol. 24 Issue 2 Pg. 98-103 (Feb 2014) ISSN: 1873-2585 [Electronic] United States
PMID24480391 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Carcinogens
  • DNA Adducts
  • Environmental Pollutants
  • Benzo(a)pyrene
Topics
  • Adult
  • Aged
  • Benzo(a)pyrene (analysis, metabolism)
  • Carcinogens (analysis, metabolism)
  • Carcinoma, Hepatocellular (blood, genetics)
  • Case-Control Studies
  • China
  • DNA Adducts
  • Environmental Pollutants (adverse effects)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Liver Neoplasms (blood, genetics)
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Regression Analysis
  • Risk Factors
  • Socioeconomic Factors
  • Surveys and Questionnaires

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