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Antrodia salmonea in submerged culture exhibits antioxidant activities in vitro and protects human erythrocytes and low-density lipoproteins from oxidative modification.

Abstract
Antrodia salmonea is well known in Taiwan as a beneficial mushroom. In the present study, we investigated the antioxidant activity of whole fermented broth (AS), filtrate (ASF), and mycelia (ASM) of A. salmonea using different antioxidant models. Furthermore, the effect of A. salmonea on AAPH-induced oxidative hemolysis of human erythrocytes and CuSO4-induced oxidative modification of human low-density lipoproteins (LDLs) was examined. We found that the AS, ASF, and ASM possess effective antioxidant activity against various oxidative systems including superoxide anion scavenging, reducing power, metal chelation, and DPPH radical scavenging. Further, AAPH-induced oxidative hemolysis in erythrocytes was prevented by AS, ASF, and ASM. Notably, AS, ASF, and ASM appear to possess powerful antioxidant activities against CuSO4-induced oxidative modification of LDL as assessed by malondialdehyde (MDA) formation, cholesterol degradation, and the relative electrophoretic mobility of oxidized LDL. It is noteworthy that AS had comparatively strong antioxidant ability compared to ASF or ASM, which is well correlated with the content of their total polyphenols. Thus, A. salmonea may exert antioxidant properties and offer protection from atherogenesis.
AuthorsYou-Cheng Hseu, Chuan-Chen Lee, Yung-Chang Chen, K J Senthil Kumar, Chee-Shan Chen, Ching-Tsan Tsai, Hui-Chi Huang, Hui-Min Wang, Hsin-Ling Yang
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 66 Pg. 150-7 (Apr 2014) ISSN: 1873-6351 [Electronic] England
PMID24480039 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Antioxidants
  • Chelating Agents
  • Lipoproteins, LDL
Topics
  • Antioxidants (pharmacology)
  • Antrodia (chemistry)
  • Chelating Agents (metabolism)
  • Electrophoretic Mobility Shift Assay
  • Erythrocytes (drug effects)
  • Hemolysis
  • Humans
  • Lipoproteins, LDL (metabolism)
  • Oxidative Stress (drug effects)

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