Abstract | OBJECTIVE: To evaluate the efficacy of Neem (Azadirachta indica) experimental gel for the prevention of erosive wear on bovine dentin, in vitro. MATERIAL AND METHODS: One hundred dentin blocks were allocated into 5 experimental groups (20 samples each): C (control group, without gel); CG (control group, only base gel); F ( fluoride gel, 1.23% NaF; pH 4.1, Dentsply; Brazil); N (Neem gel, 10% neem extract; pH 4.1, manipulation); NF (Neem+fluoride gel, 10% Neem extract and 1.23% NaF; pH 4.1, manipulation). The blocks were stored in artificial saliva for 24 hours. After this, they were submitted to six alternating re- and demineralization cycles. The blocks were analyzed for wear (profilometry). The results were submitted to statistical analysis by ANOVA and Tukey tests (P<0.05). RESULTS: The mean wear (±SD, µm) was shown as follows in groups: C (13.09±0.99), CG (10.60±1.99), F (10.90±1.44), N (12.68±1.13) and NF (10.84±1.65). All gels showed some preventive action when compared with control group. However, significant differences were found only between Neem+fluoride gel and fluoride gel. CONCLUSION: A single application of a neem-containing fluoride gel reduced dentin erosion, thus it is a possible alternative in reducing dental wear. Further research should investigate the action mechanism and the synergism between them.
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Authors | André de Carvalho Sales-Peres, Juliane Avansini Marsicano, Rudan Paraíso Garcia, Moacir Rossi Forim, Maria Fatima das Graças Fernandes da Silva, Sílvia Helena de Carvalho Sales-Peres |
Journal | Journal of applied oral science : revista FOB
(J Appl Oral Sci)
2013 Nov-Dec
Vol. 21
Issue 6
Pg. 597-600
ISSN: 1678-7765 [Electronic] Brazil |
PMID | 24473728
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fluorides, Topical
- Gels
- Plant Extracts
- Saliva, Artificial
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Topics |
- Animals
- Azadirachta
(chemistry)
- Cattle
- Dental Enamel
(drug effects)
- Dentin
(drug effects)
- Fluorides, Topical
(pharmacology, therapeutic use)
- Gels
- Hardness
- Plant Extracts
(pharmacology, therapeutic use)
- Reproducibility of Results
- Saliva, Artificial
(chemistry)
- Surface Properties
- Time Factors
- Tooth Demineralization
- Tooth Erosion
(prevention & control)
- Tooth Remineralization
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