[Real-world study in analysis of effects on concomitant medications with parenterally administered shenmai for coronary heart disease].

Abstract	In order to understand the treatment of coronary heart disease with parenterally administered Shenmai and the efficacy of combination therapies, the study selected 18 hospitals for analysis. Data from each hospital's hospital injection system (HIS) was collected. Data of in-patients receiving parenterally administered Shenmai for a diagnosis of coronary heart disease was analyzed using; the Apriori algorithm to model use, Clementine 12.0 linkage analysis to find correlations between various drugs, and chi-square test for commonly used combination therapies to ascertain the cure rate. In 5 583 patients with coronary heart disease, it was found that Shenmai was commonly used with isosorbide mononitrate, aspirin, clopidogrel hydrogen and common combinations of combination therapy, and that the cure rate was better in these combinations than for other treatment regimes. When Shenmai is used with combination therapies for coronary heart disease, treatment guidelines should be complied with. In clinical application, the types of concomitant medications and their interactions, should be observed so as to prevent of adverse reactions.
Authors	Jun-Jie Jiang, Hao Tang, Yan-Ming Xie, Hu Yang, Yan Zhuang
Journal	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 38 Issue 18 Pg. 3137-40 (Sep 2013) ISSN: 1001-5302 [Print] China
PMID	24471341 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Drug Combinations Drugs, Chinese Herbal fructus schizandrae, radix ginseng, radix ophiopogonis drug combination Clopidogrel Ticlopidine Aspirin
Topics	Adolescent Adult Aged Aged, 80 and over Aspirin (therapeutic use) Clopidogrel Coronary Disease (drug therapy) Drug Combinations Drug Therapy, Combination Drugs, Chinese Herbal (administration & dosage) Female Hospital Information Systems (statistics & numerical data) Humans Infusions, Parenteral Logistic Models Male Middle Aged Outcome Assessment, Health Care Pragmatic Clinical Trials as Topic Ticlopidine (analogs & derivatives, therapeutic use) Treatment Outcome Young Adult

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