HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Rotavirus vaccination: a risk factor for intussusception?

Abstract
Recently published pharmacoepidemiological studies associate the currently authorized Rotavirus (RV) vaccines with intussusception (IS). We aimed at investigating whether, in Germany, there are excess IS cases in RV vaccinees compared with the background incidence before market authorization in 2006. Suspected cases of IS following receipt of RV vaccines reported to the Paul-Ehrlich-Institut (PEI) from 2006 to 2010 were reviewed and validated against the criteria of the Brighton Collaboration's definition for IS. An observed-versus-expected analysis was conducted using standardized morbidity ratio (SMR) methods based on age-specific incidence rates for IS ranging from 19.2 to 98.5 per 100,000 person-years. A total of 27 cases of suspected IS in RV vaccinees were reported to the PEI. No excess of IS cases could be detected 1-7 days after receipt of either RV vaccine after any dose in the first year of life; however, in infants aged 3-5 months, a significantly increased SMR for IS was found in a risk window of 1-7 days after the first dose of either RV vaccine [SMRs: Rotarix® 4.6 (95% CI 1.5-10.7); RotaTeq® 5.8 (95% CI 1.2-17.1)]. A significantly increased risk of IS in a risk window of 1-7 days after RV vaccination was not found when the first dose was administered earlier. Therefore, it is recommended to start the vaccination course at 6-12 weeks of age.
AuthorsD Oberle, A C Jenke, R von Kries, D Mentzer, B Keller-Stanislawski
JournalBundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz (Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz) Vol. 57 Issue 2 Pg. 234-41 (Feb 2014) ISSN: 1437-1588 [Electronic] Germany
PMID24469287 (Publication Type: Journal Article, Review)
Chemical References
  • Rotavirus Vaccines
Topics
  • Causality
  • Child, Preschool
  • Comorbidity
  • Female
  • Germany (epidemiology)
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Intussusception (epidemiology)
  • Male
  • Mass Vaccination (statistics & numerical data)
  • Risk Factors
  • Rotavirus Infections (epidemiology, prevention & control)
  • Rotavirus Vaccines (therapeutic use)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: