Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: Mechanical hypersensitivity was assessed in mice treated with acute and chronic doses of nitroglycerin (NTG), a known human migraine trigger. Conditioned place aversion to NTG was also measured as a model of migraine-associated negative affect. In addition, we assessed evoked cortical spreading depression (CSD), an established model of migraine aura, in a thinned skull preparation. KEY RESULTS: CONCLUSIONS AND IMPLICATIONS: These data show that δ- opioid receptor agonists modulate multiple basic mechanisms associated with migraine, indicating that δ- opioid receptors are a promising therapeutic target for this disorder.
|
Authors | Amynah A Pradhan, Monique L Smith, Jekaterina Zyuzin, Andrew Charles |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 171
Issue 9
Pg. 2375-84
(May 2014)
ISSN: 1476-5381 [Electronic] England |
PMID | 24467301
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Copyright | © 2014 The British Pharmacological Society. |
Chemical References |
- Benzamides
- Piperazines
- Receptors, Opioid, delta
- 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide
- Nitroglycerin
|
Topics |
- Animals
- Avoidance Learning
(drug effects, physiology)
- Benzamides
(pharmacology, therapeutic use)
- Cortical Spreading Depression
(drug effects, physiology)
- Female
- Hyperalgesia
(drug therapy, physiopathology)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Migraine Disorders
(drug therapy, physiopathology)
- Nitroglycerin
(toxicity)
- Piperazines
(pharmacology, therapeutic use)
- Receptors, Opioid, delta
(agonists, physiology)
|