Genetic association of human leukocyte antigens with chronicity or resolution of hepatitis B infection in thai population.

Abstract

BACKGROUND:

Previous studies showed that single nucleotide polymorphisms (SNPs) in the HLA-DP, TCF19 and EHMT2 genes may affect the chronic hepatitis B (CHB). To predict the degree of risk for chronicity of HBV, this study determined associations with these SNPs.

METHODS:

The participants for this study were defined into 4 groups; HCC (n = 230), CHB (n = 219), resolved HBV infection (n = 113) and HBV uninfected subjects (n = 123). The HLA-DP SNPs (rs3077, rs9277378 and rs3128917), TCF19 SNP (rs1419881) and EHMT2 SNP (rs652888) were genotyped.

RESULTS:

Due to similar distribution of genotype frequencies in HCC and CHB, we combined these two groups (HBV carriers). The genotype distribution in HBV carriers relative to those who resolved HBV showed that rs3077 and rs9277378 were significantly associated with protective effects against CHB in minor dominant model (OR = 0.45, p<0.001 and OR = 0.47, p<0.001). The other SNPs rs3128917, rs1419881 and rs652888 were not associated with HBV carriers.

CONCLUSIONS:

Genetic variations of rs3077 and rs9277378, but not rs3128917, rs1419881 and rs652888, were significantly associated with HBV carriers relative to resolved HBV in Thai population.

• Authors: Nawarat Posuwan, Sunchai Payungporn, Pisit Tangkijvanich, Shintaro Ogawa, Shuko Murakami, Sayuki Iijima, Kentaro Matsuura, Noboru Shinkai, Tsunamasa Watanabe, Yong Poovorawan, Yasuhito Tanaka
• Journal: PloS one (PLoS One) Vol. 9 Issue 1 Pg. e86007 ( 2014) ISSN: 1932-6203 [Electronic] United States
• PMID: 24465836 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DP alpha-Chains
• HLA-DP beta-Chains
• HLA-DPA1 antigen
• HLA-DPB1 antigen
• Histocompatibility Antigens
• EHMT2 protein, human
• Histone-Lysine N-Methyltransferase

Topics

• Adult
• Aged
• Carcinoma, Hepatocellular (genetics, virology)
• Female
• Gene Frequency
• Genetic Association Studies
• HLA-DP alpha-Chains (genetics)
• HLA-DP beta-Chains (genetics)
• Hepatitis B, Chronic (genetics)
• Histocompatibility Antigens (genetics)
• Histone-Lysine N-Methyltransferase (genetics)
• Humans
• Linkage Disequilibrium
• Liver Neoplasms (genetics, virology)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Thailand