Abstract | PURPOSE:
Ceftriaxone has been associated with development of pseudolithiasis. In our institution, it is used for treatment of perforated appendicitis in children. This study evaluated the occurrence of ceftriaxone-related pseudolithiasis in this population. METHODS: After obtaining IRB approval, we performed a retrospective chart review over 51 months. We included patients undergoing laparoscopic appendectomy for perforated appendicitis. All patients were treated with ceftriaxone post-operatively. Patients without initial or post-treatment gallbladder imaging available for review were excluded. RESULTS: There were 71 patients who met inclusion criteria with a mean (±SD) age of 10.8 ± 3.8 years. Of these, 14 % (n = 10) developed stones or sludge in the gallbladder. The mean duration of ceftriaxone therapy was 8.7 ± 3.8 days. The average time to post- antibiotic imaging was 11.5 ± 10.3 days from initiation of antibiotics. There was no significant difference in duration of ceftriaxone therapy in the children that developed pseudolithiasis or sludge (10.0 ± 4.9 days) compared to those that did not (8.5 ± 3.6, p = 0.26). One child (10 %) with pseudolithiasis went on to become symptomatic, requiring a laparoscopic cholecystectomy. CONCLUSIONS:
|
Authors | Hanna Alemayehu, Amita A Desai, Priscilla Thomas, Susan W Sharp, Shawn D St Peter |
Journal | Pediatric surgery international
(Pediatr Surg Int)
Vol. 30
Issue 3
Pg. 323-6
(Mar 2014)
ISSN: 1437-9813 [Electronic] Germany |
PMID | 24464035
(Publication Type: Journal Article)
|
Chemical References |
- Anti-Bacterial Agents
- Ceftriaxone
|
Topics |
- Anti-Bacterial Agents
(adverse effects, therapeutic use)
- Appendicitis
(drug therapy, surgery)
- Ceftriaxone
(adverse effects, therapeutic use)
- Child
- Cholelithiasis
(chemically induced)
- Female
- Follow-Up Studies
- Humans
- Male
- Retrospective Studies
- Time Factors
|