Six months chronic toxicological evaluation of naringin in Sprague-Dawley rats.

Abstract

Naringin is a flavonoid showing variable pharmacological properties and is distributed ubiquitously in plant foods. There is a paucity of reported data regarding its safety profile. In the present study, chronic toxicity studies of naringin was designed and conducted by oral gavage at doses of 0, 50, 250 and 1250 mg/kg in Sprague-Dawley (SD) rats for six months followed by 1-month recovery period. During the 6-month treatment period and one month recovery period, no mortality and toxicologically significant changes in clinical signs, opthalmoscopic examination, hematology, clinical biochemistry, serumsexhormone, macroscopic findings, organ weights and histopathological examination were noted and attributed to naringin administration. Although consecutive and/or isolated periods of significant body weights and food consumption decreases were relevant to naringin administration, they were not considered toxicologically significant. In addition, slight, non-pathological and reversible hair loss was noted during the 6-month treatment period and considered as a kind of change possibly relevant to naringin administration; however, it was not considered adverse change and to be of toxicological significance. Based on the results of this study, the no-observed-adverse-effect-level (NOAEL) of naringin in rats is greater than 1250 mg/kg/day when administered orally for 6 consecutive months.

• Authors: Peibo Li, Sheng Wang, Xiaolin Guan, Xiaobo Cen, Chunyan Hu, Wei Peng, Yonggang Wang, Weiwei Su
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 66 Pg. 65-75 (Apr 2014) ISSN: 1873-6351 [Electronic] England
• PMID: 24462649 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Flavanones
• Gonadal Steroid Hormones
• naringin

Topics

• Administration, Oral
• Animals
• Body Weight (drug effects)
• Dose-Response Relationship, Drug
• Feeding Behavior (drug effects)
• Female
• Flavanones (administration & dosage, toxicity)
• Gonadal Steroid Hormones (blood)
• Male
• Organ Size (drug effects)
• Rats
• Rats, Sprague-Dawley
• Toxicity Tests, Chronic