Case of keratitis caused by Streptomyces thermocarboxydus.

Abstract

We describe a case of keratitis caused by Streptomyces thermocarboxydus and report the usefulness of molecular analysis in identifying the exact species of Streptomyces. A 50-year-old man was diagnosed with keratitis caused by Streptomyces sp. which was identified as S. thermocarboxydus by sequencing the 16S rDNA. He had no history of trauma or systemic diseases. He was initially treated with topical beta-lactams and fluoroquinolones, and systemic beta-lactams but the keratitis did not improve. His vision improved significantly after topical erythromycin (5 mg/ml) and oral minocycline (200 mg/day) therapy. Our findings demonstrate that molecular analysis can be used to identify the exact Streptomyces species causing the keratitis. This then allowed us to determine the susceptibility of this species to different antibacterial drugs which were used to treat our patient successfully.

• Authors: Hideaki Kawakami, Hiroko Inuzuka, Kiyofumi Mochizuki, Toshihiro Muto, Kiyofumi Ohkusu, Takashi Yaguchi, Yuka Yamagishi, Hiroshige Mikamo
• Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 20 Issue 1 Pg. 57-60 (Jan 2014) ISSN: 1437-7780 [Electronic] Netherlands
• PMID: 24462427 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Bacterial Agents

Topics

• Anti-Bacterial Agents (therapeutic use)
• Humans
• Keratitis (drug therapy, microbiology)
• Male
• Middle Aged
• Streptomyces (drug effects)