Chronic endometritis in women with recurrent early pregnancy loss and/or fetal demise.

Abstract

OBJECTIVE:

To assess the prevalence of chronic endometritis in women with a history of recurrent early pregnancy loss (REPL) and/or fetal demise (FD).

DESIGN:

Observational cohort study using prospectively collected data.

SETTING:

Recurrent pregnancy loss program in an academic medical center.

PATIENT(S):

Three hundred ninety-five women with a history of two or more pregnancy losses of less than 10 weeks' size or a fetal demise of 10 or more weeks' size.

INTERVENTION(S):

All women had an endometrial biopsy. Chronic endometritis was treated with antibiotics, and a second endometrial biopsy was recommended as a "test of cure."

MAIN OUTCOME MEASURE(S):

Subsequent live-birth rate (LBR).

RESULT(S):

The overall prevalence of chronic endometritis was 9% (35/395) in this cohort; 7% (21/285) in the REPL group, 14% (8/57) in the FD group, and 11% (6/53) in the combined REPL/FD group. The cure rate was 100% after a course(s) of antibiotics. The subsequent cumulative LBR was 88% (21/24) for the treated chronic endometritis group versus 74% (180/244) for the group without chronic endometritis. The per-pregnancy LBR for the treated chronic endometritis group was 7% (7/98) before treatment versus 56% (28/50) after treatment.

CONCLUSION(S):

There was a high prevalence of chronic endometritis in this cohort. The test of cure was 100% with antibiotics. Subsequent LBRs after treatment were encouraging.

• Authors: Dana B McQueen, Lia A Bernardi, Mary D Stephenson
• Journal: Fertility and sterility (Fertil Steril) Vol. 101 Issue 4 Pg. 1026-30 (Apr 2014) ISSN: 1556-5653 [Electronic] United States
• PMID: 24462055 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Topics

• Abortion, Habitual (mortality)
• Adolescent
• Adult
• Chicago (epidemiology)
• Chronic Disease
• Cohort Studies
• Comorbidity
• Embryo Loss (mortality)
• Endometritis (epidemiology)
• Female
• Fetal Death (epidemiology)
• Humans
• Pregnancy
• Prevalence
• Risk Assessment
• Young Adult