[Significance of tumor markers in the treatment of patients with ovarian malignancies].

Abstract

Seven tumor markers (CA125, CA19-9, TPA, IAP, CEA, ferritin, LDH) were measured in 24 patients with ovarian cancer. The positive rates in untreated cases of ovarian cancer were 87.5% for CA125, 35.5% for CA19-9, 10% for CEA, 77.8% for IAP, 63.6% for TPA, 28.6% for LDH and 35.3% for ferritin. Among these, CA125 was the most available marker for detecting tumor growth or regression during each respective clinical course by serial measurement. Serial changes in serum alpha-fetoprotein (AFP) levels during treatment were studied among 27 patients with ovarian embryonal carcinoma. AFP decreased with a half-life of about 7 days, and was restored to the normal range within 10 weeks after the initial surgery and chemotherapy (VAC) in all cases. In subsequently fatal cases, AFP rose again during 10 to 30 weeks after the initial treatment.

• Authors: Y Tomoda, T Kano, Y Furuhashi, K Mizuno, N Kamiya, K Mizuno, K Sakakibara, M Ohta
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 14 Issue 11 Pg. 3027-33 (Nov 1987) ISSN: 0385-0684 [Print] Japan
• PMID: 2445293 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigens, Neoplasm
• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor
• Peptides
• Tissue Polypeptide Antigen
• alpha-Fetoproteins

Topics

• Antigens, Neoplasm (analysis)
• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor (analysis)
• Combined Modality Therapy
• Female
• Humans
• Ovarian Neoplasms (diagnosis, therapy)
• Peptides (analysis)
• Prognosis
• Teratoma (diagnosis, therapy)
• Tissue Polypeptide Antigen
• alpha-Fetoproteins (analysis)