Association between lutein and zeaxanthin status and the risk of cataract: a meta-analysis.
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| Abstract |
The purpose of this meta-analysis was to evaluate the relationship between blood lutein and zeaxanthin concentration and the risk of age-related cataract (ARC). MEDLINE, EMBASE, ISI and Cochrane Library were searched to identify relevant studies up to April 2013. Meta-analysis was conducted to obtain pooled relative risks (RRs) for the highest-versus-lowest categories of blood lutein and zeaxanthin concentrations. One cohort study and seven cross-sectional studies were included in the meta-analysis. There were significant inverse associations between nuclear cataract and blood lutein and zeaxanthin concentrations, with the pooled RRs ranging from 0.63 (95% confidence interval (CI): 0.49, 0.77) for zeaxanthin to 0.73 (95% CI: 0.59, 0.87) for lutein. A stronger association between nuclear cataract and blood zeaxanthin might be noted for the studies conducted in the European Nations. Blood lutein and zeaxanthin were also noted to lead towards a decrease in the risk of cortical cataract and subcapsular cataract; however, these pooled RRs were not statistically significant, with the exception of a marginal association between lutein and subcapsular cataract. Our results suggest that high blood lutein and zeaxanthin are significantly associated with a decrease in the risk of nuclear cataract. However, no significant associations were found for ARC in other regions of the lens.
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| Authors | Xiao-Hong Liu, Rong-Bin Yu, Rong Liu, Zhen-Xuan Hao, Cheng-Cheng Han, Zhong-Hai Zhu, Le Ma |
| Journal | Nutrients (Nutrients) Vol. 6 Issue 1 Pg. 452-65 (Jan 22 2014) ISSN: 2072-6643 [Electronic] Switzerland |
| PMID | 24451312 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't) |
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