Patellofemoral friction syndrome: magnetic resonance imaging correlation of morphologic and T2 cartilage imaging.

Abstract

OBJECTIVE:

This study aimed to investigate whether patellofemoral T2 cartilage changes are associated with lateral patellofemoral friction syndrome (PFS), as indicated by an edema-like signal within the superolateral infrapatellar (Hoffa) fat pad.

METHODS:

In this institutional review board-approved retrospective study of 510 consecutive patients, 49 patients with 50 knee magnetic resonance imaging examinations demonstrating normal or low-grade patellofemoral cartilage abnormalities (whole-organ magnetic resonance imaging score [WORMS] score, ≤2) were included. Twenty-two examinations with PFS (cases) were compared with an age- and sex-matched cohort of 28 examinations without PFS (controls). A 3-T magnetic resonance imaging was performed with multi-echo, spin-echo T2 mapping. Two readers measured in consensus malalignment parameters, including patellar height index, tibial tuberosity to trochlear groove distance, and sulcus angle. Bulk T2 cartilage values in the lateral and medial patellofemoral compartment, central weight-bearing medial and lateral femoral condyles were measured independently. Interobserver agreement was quantified using concordance correlation coefficients. Demographics, anatomic measurements, whole-organ magnetic resonance imaging scores, and cartilage T2 values were compared between cases and controls using Fisher exact test, Wilcoxon rank sum test, and mixed-effects models.

RESULTS:

Cases demonstrated higher patellar height index (P = 0.002) and tibial tuberosity to trochlear groove distance (P = 0.02). Interobserver agreement for T2 values was good overall (concordance correlation coefficient range, 0.65-0.93). Cases demonstrated higher medial facet patellar bulk T2 (38.1 [7.5] ms) versus controls (33.6 [7.3] ms) (P = 0.02); otherwise, there were no significant differences in regional T2 values.

CONCLUSIONS:

T2 mapping in patients with PFS demonstrates increased cartilage T2 in the medial patellar facet, possibly reflecting collagen alteration from early chondromalacia (softening) or increased water content related to altered contact pressures.

• Authors: Ty K Subhawong, Rashmi S Thakkar, Abraham Padua, Aaron Flammang, Avneesh Chhabra, John A Carrino
• Journal: Journal of computer assisted tomography (J Comput Assist Tomogr) 2014 Mar-Apr Vol. 38 Issue 2 Pg. 308-12 ISSN: 1532-3145 [Electronic] United States
• PMID: 24448504 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Topics

• Adolescent
• Adult
• Cartilage, Articular (pathology)
• Female
• Friction
• Humans
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Patellofemoral Pain Syndrome (diagnosis, pathology)