Non-carboxylic analogues of aryl propionic acid: synthesis, anti-inflammatory, analgesic, antipyretic and ulcerogenic potential.

Abstract

As a part of ongoing studies in developing new potent anti-inflammatory and analgesic agents, a series of novel 6-methoxy naphthalene derivatives was efficiently synthesized and characterized by spectral and elemental analyses. The newly synthesized compounds were evaluated for their anti-inflammatory activities using carrageenin-induced rat paw edema model, analgesic activities using acetic acid induced writhing model in mice and anti-pyretic activity using yeast induced hyperpyrexia method as well as ulcerogenic effects. Among the synthesized compounds, thiourea derivative (6a, e) exhibited higher anti-inflammatory activity than the standard drug naproxen in reduction of the rat paw edema (88.71, 89.77%) respectively. All of the non-carboxylic tested compounds were found to have promising anti-inflammatory, analgesic and antipyretic activity, while were devoid of any ulcerogenic effects.

• Authors: S I Eissa, A M Farrag, A A A Galeel
• Journal: Drug research (Drug Res (Stuttg)) Vol. 64 Issue 9 Pg. 485-92 (Sep 2014) ISSN: 2194-9387 [Electronic] Germany
• PMID: 24446206 (Publication Type: Comparative Study, Journal Article)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Antipyretics
• Naphthalenes
• Propionates
• Naproxen
• Carrageenan

Topics

• Analgesics (chemical synthesis, chemistry, pharmacology)
• Animals
• Anti-Inflammatory Agents (chemical synthesis, chemistry, pharmacology)
• Antipyretics (chemical synthesis, chemistry, pharmacology)
• Carrageenan
• Disease Models, Animal
• Edema (drug therapy, pathology)
• Fever (drug therapy, pathology)
• Inflammation (drug therapy, pathology)
• Male
• Mice
• Naphthalenes (chemical synthesis, chemistry, pharmacology)
• Naproxen (pharmacology)
• Pain (drug therapy, pathology)
• Propionates (chemical synthesis, chemistry, pharmacology)
• Rats
• Rats, Wistar
• Ulcer (chemically induced)