[Sodium-glucose co-transporter-2 inhibitors: from the bark of apple trees and familial renal glycosuria to the treatment of type 2 diabetes mellitus].

Abstract

The therapeutic armamentarium for the treatment of hyperglycemia in type 2 diabetes mellitus is still inadequate. We are currently witnessing the introduction of a new mode of hypoglycemic treatment through induction of glycosuria to decrease the availability of the metabolic substrate, i.e. glucose. Clinical trials have shown that sodium-glucose co-transporter-2 (SGLT2) inhibitors are as efficacious as other oral hypoglycemic drugs. This article discusses the basic features of this new treatment concept and the efficacy and safety of this new drug group.

• Authors: Dídac Mauricio
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 141 Suppl 2 Pg. 31-5 (Sep 2013) ISSN: 1578-8989 [Electronic] Spain
• Vernacular Title: Inhibidores SGLT-2: de la corteza del manzano y la glucosuria familiar al tratamiento de la diabetes mellitus tipo 2.
• PMID: 24444522 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2013 Elsevier España, S.L. All rights reserved.

Chemical References

• Benzhydryl Compounds
• Drugs, Investigational
• Glucosides
• Glycosides
• Hypoglycemic Agents
• SLC5A2 protein, human
• Sodium-Glucose Transporter 2
• Sodium-Glucose Transporter 2 Inhibitors
• Thiophenes
• Canagliflozin
• dapagliflozin
• ipragliflozin
• (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol
• Phlorhizin
• empagliflozin
• Glucose

Topics

• Adsorption (drug effects)
• Animals
• Benzhydryl Compounds (pharmacology, therapeutic use)
• Biological Transport, Active (drug effects)
• Canagliflozin
• Clinical Trials, Phase III as Topic
• Diabetes Mellitus, Type 2 (drug therapy, metabolism)
• Drugs, Investigational (pharmacology, therapeutic use)
• Glucose (metabolism)
• Glucosides (pharmacology, therapeutic use)
• Glycosides (pharmacology, therapeutic use)
• Glycosuria (chemically induced)
• Glycosuria, Renal (genetics, metabolism)
• Humans
• Hypoglycemic Agents (pharmacology, therapeutic use)
• Kidney Tubules, Proximal (drug effects, metabolism)
• Malus (chemistry)
• Phlorhizin (isolation & purification, therapeutic use)
• Phytotherapy
• Plant Bark (chemistry)
• Rats
• Sodium-Glucose Transporter 2 (genetics, physiology)
• Sodium-Glucose Transporter 2 Inhibitors
• Thiophenes (pharmacology, therapeutic use)
• Treatment Outcome