Long-term efficacy and safety of alemtuzumab in advanced primary cutaneous T-cell lymphomas.

Abstract

BACKGROUND:

Alemtuzumab has been proposed as salvage therapy for refractory cutaneous T-cell lymphomas (CTCLs). Long-term follow-up data are scarce.

OBJECTIVES:

To assess the efficacy and safety of alemtuzumab in the treatment of advanced CTCL.

METHODS:

A multicentre retrospective analysis was carried out of 39 patients with advanced CTCL treated with alemtuzumab between 2003 and 2013.

RESULTS:

Thirty-nine patients (median age 62 years, range 20-83) with Sézary syndrome (SS, n = 23) or advanced mycosis fungoides (MF, n = 16) received alemtuzumab 30 mg two to three times per week for a median duration of 12 weeks (range 1-35). Fifteen patients received maintenance therapy for a median duration of 24 weeks (range 6-277). Eleven patients (28%) had transformed disease (MF, n = 10; SS, n = 1). After a median follow-up of 24 months (range 0.3-124), eight patients (21%) were still alive. The overall response rate was 51% in the whole study group (partial response, n = 13; complete response, n = 7); 70% in patients with SS and 25% in patients with MF (P = 0.009). The median time to progression was 3.4 months (range 0.4-42). Six patients (15%; SS, n = 5; MF, n = 1) remained progression free for > 2 years (median 56 months, range 28-117). Five patients experienced cutaneous large T-cell transformation during alemtuzumab treatment and one patient developed primary cutaneous large B-cell lymphoma. Twenty-four patients (62%) had a grade three or higher infectious adverse event and 10 (26%) a haematological toxicity, which led to treatment discontinuation in 17 cases (44%) and death in two (5%).

CONCLUSIONS:

Alemtuzumab may induce long-term remission in SS but seems ineffective in MF and transformed CTCL.

• Authors: A de Masson, P Guitera, P Brice, I Moulonguet, F Mouly, J-D Bouaziz, M Battistella, I Madelaine, J Roux, C Ram-Wolff, J-M Cayuela, H Bachelez, A Bensussan, L Michel, M Bagot
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 170 Issue 3 Pg. 720-4 (Mar 2014) ISSN: 1365-2133 [Electronic] England
• PMID: 24438061 (Publication Type: Journal Article, Multicenter Study)
• Copyright: © 2014 British Association of Dermatologists.

Chemical References

• Antibodies, Monoclonal, Humanized
• Antineoplastic Agents
• Alemtuzumab

Topics

• Adult
• Aged
• Aged, 80 and over
• Alemtuzumab
• Antibodies, Monoclonal, Humanized (administration & dosage, adverse effects)
• Antineoplastic Agents (administration & dosage, adverse effects)
• Dose-Response Relationship, Drug
• Female
• Humans
• Injections, Intradermal
• Injections, Intravenous
• Long-Term Care
• Lymphoma, T-Cell, Cutaneous (drug therapy)
• Male
• Middle Aged
• Mycosis Fungoides (drug therapy)
• Retrospective Studies
• Skin Neoplasms (drug therapy)
• Young Adult