Outlook for a dengue vaccine.

Abstract

Dengue is an increasing medical problem in subtropical and tropical countries. The search for a safe and effective vaccine is complicated by the fact that there are four types of dengue virus and that, if a vaccine is live attenuated, it should be proven not to cause the life-threatening form of dengue, dengue haemorrhagic fever. So far one vaccine candidate, a four-valent chimeric vaccine constructed from a yellow fever vaccine strain, has reached large clinical trials and has been shown to offer protection against dengue types 1, 3 and 54 but not against dengue type 2. It is highly likely that an effective vaccine will be available in the next decade.

• Authors: R Norrby
• Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (Clin Microbiol Infect) Vol. 20 Suppl 5 Pg. 92-4 (May 2014) ISSN: 1469-0691 [Electronic] England
• PMID: 24438016 (Publication Type: Journal Article, Review)
• Copyright: © 2013 The Authors Clinical Microbiology and Infection © 2013 European Society of Clinical Microbiology and Infectious Diseases.

Chemical References

• Dengue Vaccines

Topics

• Clinical Trials, Phase III as Topic
• Dengue (prevention & control)
• Dengue Vaccines (immunology)
• Dengue Virus
• Humans
• Randomized Controlled Trials as Topic