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Melanotic neuroectodermal tumor of infancy with high serum levels of alpha-fetoprotein. Ultrastructural study and immunological evidence of glial fibrillary protein and alpha-fetoprotein.

Abstract
We report an infant melanotic neuroectodermal tumor in the anterior part of the upper gingiva, which was associated with high urinary excretion of vanilmandelic acid. Serum levels of alpha-fetoprotein were abnormally high (200 ng/ml). They returned to normal after removal of the tumor (10 ng/ml). The tumor was characterized histologically and ultrastructurally by the presence of melanocytic and astrocytic cells containing glial fibrillary protein. Intracellular alpha-fetoprotein was demonstrated by the immunoperoxidase method (PAP) in scattered foci of interstitial cells.
AuthorsN Dourov, R Mayer, F de Martelaere, S Godart, W Gepts, R Maurus
JournalJournal of oral pathology (J Oral Pathol) Vol. 16 Issue 5 Pg. 251-5 (May 1987) ISSN: 0300-9777 [Print] Denmark
PMID2443628 (Publication Type: Case Reports, Journal Article)
Chemical References
  • alpha-Fetoproteins
Topics
  • Female
  • Gingival Neoplasms (blood, ultrastructure)
  • Humans
  • Infant
  • Neoplasms, Germ Cell and Embryonal (blood, ultrastructure)
  • alpha-Fetoproteins (analysis)

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