[Effect of sijunzi decoction on the intestinal glucose absorption in model rats of Pi-qi deficiency syndrome: an experimental research].

Abstract

OBJECTIVE:

To observe the effect of Sijunzi Decoction (SD) on the intestinal absorption of glucose in model rats of Pi-qi deficiency syndrome (PQDS).

METHODS:

PQDS rat model was established by subcutaneous injection of reserpine from the neck. The body weight and urine D-xylose excretion rates were measured. The glucose uptake rate was measured by jejunum perfusion. The intestinal mucosa was collected. The glucose transporter-2 (GLUT2) protein and mRNA expression levels were detected.

RESULTS:

Compared with the normal control group, the body weight and D-xylose excretion rates decreased in the model group. Meanwhile, the glucose uptake and GLUT2 protein and mRNA expression levels decreased in the model group. The aforesaid indices were improved in the SD group.

CONCLUSION:

SD could promote the recovery of glucose uptake in the small intestine of reserpine induced PQDS rats.

• Authors: Jia Liu, Wen-Feng Guo, Li Ren, Wei-Wen Chen
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 33 Issue 10 Pg. 1389-93 (Oct 2013) ISSN: 1003-5370 [Print] China
• PMID: 24432686 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Glucose Transporter Type 2
• Slc2a2 protein, rat
• Reserpine
• Glucose

Topics

• Animals
• Drugs, Chinese Herbal (pharmacology)
• Female
• Glucose (metabolism)
• Glucose Transporter Type 2 (metabolism)
• Intestinal Absorption (drug effects)
• Intestinal Mucosa (drug effects, metabolism)
• Intestine, Small (drug effects, metabolism)
• Qi
• Rats
• Rats, Sprague-Dawley
• Reserpine (adverse effects)