[Metabolic effects of delta-sleep inducing peptide during physiological aging of the organism].

Abstract

Subcutaneous injection of delta-sleep inducing peptide (DSIP) to postnatal rats (aged from 2 to 24 months) during 5 consecutive days every months at a dose of 10 microg/100 g body weight favors normalization of the age-related changes in carbohydrate metabolism and shows hypoglycemic effect, as manifested by a decrease in the level of glycosylated hemoglobin in erythrocytes of test rats. The administration of DSIP in postnatal rats of different age also led to a decrease in serum total lipid level, total cholesterol level, and atherogenicity index and an increase in the level of high-density lipoprotein cholesterol.

• Authors: T I Bondarenko, E A Maĭboroda, I I Mikhaleva, I A Prudchenko
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 76 Issue 9 Pg. 22-6 ( 2013) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 24432565 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Cholesterol, HDL
• Glycated Hemoglobin A
• Delta Sleep-Inducing Peptide
• Cholesterol

Topics

• Aging (blood)
• Animals
• Animals, Outbred Strains
• Blood Glucose (drug effects)
• Carbohydrate Metabolism (drug effects)
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Delta Sleep-Inducing Peptide (pharmacology)
• Erythrocytes (chemistry, drug effects)
• Glycated Hemoglobin (metabolism)
• Injections, Subcutaneous
• Lipid Metabolism (drug effects)
• Male
• Rats