Abstract | INTRODUCTION: METHODS: Cases were classified according to the World Health Organization classification of mucinous adenocarcinoma of the colon. Accordingly, tumors were categorized as either (a) mucinous adenocarcinoma of the colon (greater than 50% of the extracellular matrix occupied by mucin) or (b) non- mucinous adenocarcinoma of the colon. Overall survival and disease-free survival were calculated. A stepwise Cox proportional hazards regression model was employed to determine the risk of death/disease recurrence. Kaplan-Meier estimates of overall survival and disease-free survival were plotted for each group and compared using a log-rank test. RESULTS: On univariate analysis, mucinous adenocarcinoma was associated with reduced risk of death (P = 0.01). On multivariate analysis, mucinous adenocarcinoma was also associated with reduced risk of death (hazard ratio (HR) 0.33, 95% confidence interval (CI) 0.14-0.79, P = 0.01). Kaplan-Meier estimates confirmed improved rate of survival in the mucinous vs. non-mucinous group (P = 0.01). Mucinous adenocarcinoma did not affect disease-free survival (HR 0.75, 95% CI 0.46-1.21, P = 0.22). A comparison of Kaplan-Meier estimates for systemic recurrence demonstrated significant increases in systemic recurrence in the group with no mucin production (P = 0.04) but not for locoregional recurrence (P = 0.24). CONCLUSIONS:
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Authors | J Hogan, J P Burke, G Samaha, E Condon, D Waldron, P Faul, J Calvin Coffey |
Journal | International journal of colorectal disease
(Int J Colorectal Dis)
Vol. 29
Issue 5
Pg. 563-9
(May 2014)
ISSN: 1432-1262 [Electronic] Germany |
PMID | 24425620
(Publication Type: Journal Article)
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Topics |
- Adenocarcinoma
(mortality, pathology, therapy)
- Adenocarcinoma, Mucinous
(mortality, pathology, therapy)
- Colonic Neoplasms
(mortality, pathology, therapy)
- Disease-Free Survival
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
- Neoplasm Staging
- Proportional Hazards Models
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