Idiopathic aplastic anemia: diagnosis and classification.

Abstract

Aplastic anemia (AA) is a disease characterized by pancytopenia and hypoplastic bone marrow caused by the decrease of hematopoietic stem cells. The pathogenesis of AA is complex and involves an abnormal hematopoietic microenvironment, hematopoietic stem cell/progenitor cell deficiencies and immunity disorders. Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive and biologic drugs, and supportive care. Herein, we will update the main issues concern AA according to our literature review.

• Authors: Osnat Jarchowsky Dolberg, Yair Levy
• Journal: Autoimmunity reviews (Autoimmun Rev) 2014 Apr-May Vol. 13 Issue 4-5 Pg. 569-73 ISSN: 1873-0183 [Electronic] Netherlands
• PMID: 24424170 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Autoantibodies
• Immunosuppressive Agents

Topics

• Anemia, Aplastic (diagnosis, drug therapy, epidemiology, metabolism)
• Animals
• Autoantibodies (immunology)
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• Immunosuppressive Agents (therapeutic use)
• T-Lymphocytes (immunology)
• Telomere (genetics)