Abstract | BACKGROUND: OBJECTIVE: Here we aimed to investigate the potential of circulatory OPG to reflect hip BMD in patients with COPD. PATIENTS AND METHODS: In 56 subjects with COPD [age, 61.7 ± 6.7 years; forced expiratory volume in 1 s (FEV1), 53.6 ± 19.2% predicted], total femur BMD was assessed by dual energy X-ray absorptiometry, serum OPG and β- crosslaps, a marker of increased bone resorption, by commercially available assays. RESULTS: From patients with normal hip BMD (n = 32, T-score 0.1 ± 0.8) to those with osteopenia (n = 14, T-score -1.6 ± 0.4) and osteoporosis (n = 10, T-score -3.4 ± 0.7) serum OPG levels significantly increased (6.6 ± 1.8 versus 7.2 ± 2.9 and versus 8.6 ± 1.5 pmol/l, p = 0.036). In addition, hip T-scores were directly related to FEV1, and inversely to β- crosslaps (R = 0.40, p = 0.002; R = 0.38, p = 0.01, respectively). In multivariate analysis, OPG independently predicted hip T-scores after adjustments for age, gender, FEV1, and β- crosslaps (p = 0.011, adjusted R(2) = 0.354). Area under receiver operator curve for OPG as a discriminator of osteoporosis was 0.787 (95% CI, 0.653-0.921) (p = 0.005). CONCLUSIONS: Present results suggest that osteoporosis of the hip is associated with increased circulatory levels of OPG in patients with COPD. OPG might serve as a biomarker of this COPD-related comorbidity.
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Authors | Pavol Pobeha, Darina Petrasova, Ruzena Tkacova, Pavol Joppa |
Journal | Respiratory medicine
(Respir Med)
Vol. 108
Issue 4
Pg. 621-7
(Apr 2014)
ISSN: 1532-3064 [Electronic] England |
PMID | 24424018
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- Osteoprotegerin
- RANK Ligand
- TNFRSF11B protein, human
- TNFSF11 protein, human
|
Topics |
- Aged
- Biomarkers
(blood)
- Body Composition
(physiology)
- Bone Density
(physiology)
- Cross-Sectional Studies
- Female
- Forced Expiratory Volume
(physiology)
- Hip Joint
(physiopathology)
- Humans
- Lumbar Vertebrae
(physiopathology)
- Male
- Middle Aged
- Osteoporosis
(diagnosis, etiology, physiopathology)
- Osteoprotegerin
(blood)
- Pulmonary Disease, Chronic Obstructive
(complications, physiopathology)
- RANK Ligand
(blood)
- Respiratory Function Tests
(methods)
|