Abstract | BACKGROUND:
Gestational diabetes mellitus (GDM) occurs in 3-5% of all pregnancies. GDM increases both maternal and fetal risks, causes fetal macrosomia, and hence increases the rates of caesarean sections and delivery complications such as shoulder dystocia. An early predictive marker and consequent early treatment could be beneficial, so amniotic fluid insulin and C-peptide have been examined in several studies. Increased amniotic fluid insulin in early amniocentesis between the 14th and 20th gestational week predicted a later GDM. A potential direct association with fetal macrosomia remains to be determined. MATERIAL AND METHODS: This retrospective study investigated amniotic fluid insulin/ C-peptide from amniocenteses between 14 and 20 weeks of gestation in correlation with fetal birth weight, type of delivery, and complications. To focus on effects of fetal hyperinsulinism apart from therapeutic confounders, we included patients who did not participate in GDM screening. Insulin and C-peptide were measured in 144 samples of frozen amniotic fluid. Birth weight, type of delivery, complications, and birth injuries were noted. RESULTS: CONCLUSIONS:
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Authors | Roland Gregor Stein, Malgorzata Meinusch, Joachim Diessner, Johannes Dietl, Arnd Hönig, Ursula Zollner |
Journal | Medical science monitor : international medical journal of experimental and clinical research
(Med Sci Monit)
Vol. 20
Pg. 54-8
(Jan 15 2014)
ISSN: 1643-3750 [Electronic] United States |
PMID | 24423633
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- C-Peptide
- Insulin
- Iodine Radioisotopes
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Topics |
- Amniocentesis
- Amniotic Fluid
(chemistry)
- Biomarkers
(analysis, metabolism)
- Birth Injuries
(diagnosis, etiology, metabolism)
- Birth Weight
- C-Peptide
(analysis)
- Diabetes Complications
(diagnosis, metabolism)
- Diabetes, Gestational
(diagnosis, metabolism)
- Female
- Fetal Macrosomia
(diagnosis, etiology, metabolism)
- Humans
- Insulin
(analysis)
- Iodine Radioisotopes
(analysis)
- Obstetric Labor Complications
(diagnosis, etiology, metabolism)
- Pregnancy
- Retrospective Studies
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