A case of small cell carcinoma of the vagina.

Abstract

Primary small cell carcinoma of the vagina is quite rare, and a standard treatment has not been established yet. Herein, we report a case of an 81-year-old woman who was diagnosed with a vaginal tumor without continuity with the uterine cervix. Histopathological diagnosis indicated alveolar solid growth of nuclear chromatin-rich atypical cells with a high N/C ratio and a partially recognized rosette-like structure, suggesting a differentiated neuroendocrine system. Chromogranin A and synaptophysin were positive. Stage I vaginal small cell carcinoma localized to the vagina was diagnosed. The tumor disappeared by radiation monotherapy with external beam irradiation and endocavitary irradiation. The patient remains alive without any disease 1 year and 8 months after the treatment, suggesting the efficacy of radiotherapy in small cell carcinoma of the vagina.

• Authors: Ryosuke Tamura, Yoshihito Yokoyama, Asami Kobayashi, Yuuki Osawa, Tatsuhiko Shigeto, Masayuki Futagami, Hideki Mizunuma
• Journal: Rare tumors (Rare Tumors) Vol. 5 Issue 4 Pg. e58 ( 2013) ISSN: 2036-3605 [Print] England
• PMID: 24416492 (Publication Type: Case Reports)