Cisplatin, vinblastine, and bleomycin combination chemotherapy in endodermal sinus tumor of the ovary.

Abstract

The combination of cisplatin, vinblastine, and bleomycin was administered to 13 previously untreated patients with pure endodermal sinus tumor of the ovary. Twelve had unilateral salpingo-oophorectomy as initial surgery. Among 11 women whose alpha-fetoprotein (AFP) levels returned to normal after cisplatin, vinblastine, and bleomycin therapy, nine are alive with no evidence of disease after periods of 20 months to six years and two months. In two patients, AFP levels returned to normal only after the introduction of different combination chemotherapies. Hematologic toxicity was moderate. Pulmonary toxicity due to bleomycin occurred in two cases. All menstruating patients resumed normal menstrual function after the interruption of chemotherapy. Two patients delivered normal term infants.

• Authors: C Sessa, C Bonazzi, F Landoni, S Pecorelli, E Sartori, C Mangioni
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 70 Issue 2 Pg. 220-4 (Aug 1987) ISSN: 0029-7844 [Print] United States
• PMID: 2439966 (Publication Type: Journal Article)

Chemical References

• alpha-Fetoproteins
• Bleomycin
• Vinblastine
• Cisplatin

Topics

• Adolescent
• Adult
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Bleomycin (administration & dosage, adverse effects)
• Child
• Cisplatin (administration & dosage, adverse effects)
• Female
• Humans
• Mesonephroma (drug therapy, mortality, surgery)
• Ovarian Neoplasms (drug therapy, mortality, surgery)
• Prognosis
• Vinblastine (administration & dosage, adverse effects)
• alpha-Fetoproteins (analysis)