HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Testicular histopathological changes following sodium fluoride administration in mice.

Abstract
It has been revealed that excessive fluoride intake on long-term is associated with toxic effects and can damage a variety of organs and tissues in the human body, including the male reproductive system. However, the molecular mechanisms of fluoride-induced male reproductive toxicity are not well understood. The study wants to get news concerning the effects of natrium fluoride on testicular tissues when this substance is administrated to a population of mice. The study was conducted on NMRI mice descending from the pregnant females treated with 0.25 mg and 0.5 mg natrium fluoride by daily gavage, from the beginning of pregnancy until the lactation is ceased. Then, the mice, males and females, were divided in six groups, three groups descending from the pregnant females treated with 0.5 mg natrium fluoride (Groups A, B and C) and three groups from the pregnant females with 0.25 mg natrium fluoride (Groups D, E and F). From the moment when the lactation is finished until the adulthood, the animals received the following treatments: homeopathic (a CH7 solution of natrium fluoride - Groups A and D), allopathic-homeopathic (0.25 mg‰ natrium fluoride administered like drinking water ad libitum and CH7 solution of natrium fluoride - Group E; 0.5 mg‰ natrium fluoride administered like drinking water ad libitum and CH7 solution of natrium fluoride - Group B), and allopathic administration of natrium fluoride (0.25 mg‰ natrium fluoride like drinking water ad libitum - Group F; 0.5 mg‰ natrium fluoride like drinking water ad libitum - Group C). When the males reached the adulthood, the administration of natrium fluoride was stopped and, by randomization, they where selected for euthanasia. The euthanasia was realized by cervical dislocation. The testes for the histopathological examination were preserved in a 10% formalin solution. The preparation of samples for optical microscopy was realized with Hematoxylin-Eosin staining. The results indicate that natrium fluoride administered in different doses, even at homeopathic dose or at allopathic-homeopathic dose, determined vacuolar dystrophy of epididymal epithelial cells, vacuolar dystrophy of linear seminal cells and necrosis.
AuthorsNicoleta Dimcevici Poesina, C Bălălău, Maria Bârcă, I Ion, Daniela Baconi, C Baston, Violeta Băran Poesina
JournalRomanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (Rom J Morphol Embryol) Vol. 54 Issue 4 Pg. 1019-24 ( 2013) ISSN: 2066-8279 [Electronic] Romania
PMID24398997 (Publication Type: Journal Article)
Chemical References
  • Sodium Fluoride
Topics
  • Animals
  • Atrophy
  • Female
  • Humans
  • Male
  • Mice
  • Pregnancy
  • Sodium Fluoride (administration & dosage, toxicity)
  • Testis (drug effects, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: