Childhood moyamoya disease accompanying Leigh syndrome.

Moyamoya disease is a cerebrovasculopathy of unknown etiology during the course of which the main and terminal veins of the internal carotid artery undergo progressive vein occlusion. Leigh syndrome is a mitochondrial encephalomyopathy that occurs due to "cytochrome c oxidase deficiency" characterized by psychomotor retardation, difficulty in eating, seizures, hypotonia, respiratory disorders and high lactate levels. Many diseases and syndromes have been defined that are associated with Moyamoya disease. To the best of our knowledge, the association of moyamoya disease with Leigh syndrome has not been defined as yet. In this study, the clinical and imaging results of a 3-year-old male child displaying the association of Moyamoya disease and Leigh syndrome are presented.
AuthorsNesat Cullu, Ekrem Karakas, Omer Karakas, Mehmet Deveer, Mustafa Calik, Fatima Nurefsan Boyaci
JournalJPMA. The Journal of the Pakistan Medical Association (J Pak Med Assoc) Vol. 63 Issue 12 Pg. 1538-40 (Dec 2013) ISSN: 0030-9982 [Print] Pakistan
PMID24397103 (Publication Type: Case Reports, Journal Article)
  • Child, Preschool
  • Diagnosis, Differential
  • Diagnostic Imaging
  • Humans
  • Leigh Disease (complications, diagnosis)
  • Male
  • Moyamoya Disease (complications, diagnosis)

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