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No impact of interleukin-28B polymorphisms on spontaneous or drug-induced hepatitis delta virus clearance.

AbstractBACKGROUND:
rs12979860 and rs8099917 interleukin-28B polymorphisms are associated with spontaneous or interferon-alpha induced hepatitis C clearance, "CC" and "TT" genotypes (respectively) being the most favourable. There are no data on the influence of interleukin-28B polymorphisms on hepatitis delta clearance in hepatitis B/D co-infected patients.
AIMS:
The present study explores the potential influence of both rs12979860 and rs8099917 polymorphisms on delta infection outcome.
METHODS:
Retrospective-longitudinal study on 55 European patients observed for at least 4 years, selected from a cohort of 439 subjects positive for hepatitis delta antibodies and hepatitis B core antibodies. The rate of spontaneous and interferon induced delta-RNA clearance was compared in interleukin-28B rs12979860 "CC" vs "non CC", and in rs8099917 "TT" vs "non TT" genotypes.
RESULTS:
Prevalence of rs12979860C allele was 60%, consistent with the reported prevalence in Italy (67%, p=0.128). No significant differences in spontaneous clearance rate were observed between rs12979860 "CC" and "non CC" genotypes (13.3% vs 7.5%, respectively, p=0.60), and between rs8099917 "TT" and "non-TT" genotypes (11.1 vs 7.1%, respectively, p=0.67). No differences were observed for interferon-induced delta-RNA clearance either.
CONCLUSIONS:
Our data suggest that interleukin-28B polymorphisms might not influence hepatitis delta clearance rate in either natural history or interferon-alpha response.
AuthorsUbaldo Visco-Comandini, Daniele Lapa, Chiara Taibi, Claudio Angeletti, Maria Rosaria Capobianchi, Anna Rosa Garbuglia
JournalDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver (Dig Liver Dis) Vol. 46 Issue 4 Pg. 348-52 (Apr 2014) ISSN: 1878-3562 [Electronic] Netherlands
PMID24387833 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightPublished by Elsevier Ltd.
Chemical References
  • Antiviral Agents
  • Hepatitis Antibodies
  • IFNL3 protein, human
  • Interferon-alpha
  • Interleukins
  • RNA, Viral
  • Interferons
Topics
  • Adult
  • Antiviral Agents (therapeutic use)
  • Cohort Studies
  • Female
  • Genotype
  • Hepatitis Antibodies (immunology)
  • Hepatitis D, Chronic (drug therapy, genetics, immunology)
  • Hepatitis Delta Virus (genetics, immunology)
  • Humans
  • Interferon-alpha (therapeutic use)
  • Interferons
  • Interleukins (genetics)
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • RNA, Viral (blood)
  • Remission, Spontaneous
  • Retrospective Studies
  • Treatment Outcome
  • Viral Load
  • White People

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