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MTP gene polymorphisms and postprandial lipemia in familial combined hyperlipidemia: effects of treatment with atorvastatin.

AbstractBACKGROUND:
The microsomal triglyceride transfer protein (MTP) is involved in hepatic and intestinal apoB secretion. We studied the effect of the functional MTP-493G/T polymorphism on fasting and postprandial lipoproteins in patients with familial combined hyperlipidemia (FCH) before and after treatment with atorvastatin.
METHODS:
Eight FCH heterozygote carriers of the rare -493T allele were compared to 9 matched FCH homozygotes for the wild-type allele in a pilot study. Oral fat loading tests were carried out to measure triglycerides (TG) and apo B48 and B100 in the different fractions of triglyceride-rich lipoproteins (TRLs) before and after treatment with atorvastatin.
RESULTS:
Before treatment, TG were similar between the -493T allele carriers and non-carriers. In the T-allele carriers, a trend was observed for increased postprandial apo B48 and B100 concentrations in Sf >400 and Sf 60-400 compared to non-carriers. After treatment, fasting and postprandial TG were significantly lowered in carriers of the T allele, but atorvastatin had no effect on postprandial TG in non-carriers. Atorvastatin resulted in similar reductions of apo B48 and B100 in TRLs in both groups.
CONCLUSION:
The MTP-493G/T polymorphism modulates postprandial apo B48 and apo B100 of TRLs in FCH. Atorvastatin decreases postprandial TG in T-allele carriers with FCH.
AuthorsBoudewijn Klop, Caroline Verseyden, Josep Ribalta, Juliana Salazar, Luis Masana, Manuel Castro Cabezas
JournalClinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis (Clin Investig Arterioscler) 2014 Mar-Apr Vol. 26 Issue 2 Pg. 49-57 ISSN: 1578-1879 [Electronic] Spain
PMID24378322 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Sociedad Española de Arteriosclerosis. Published by Elsevier España. All rights reserved.
Chemical References
  • Apolipoproteins B
  • Carrier Proteins
  • Heptanoic Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Lipoproteins
  • Pyrroles
  • Triglycerides
  • microsomal triglyceride transfer protein
  • Atorvastatin
Topics
  • Adult
  • Alleles
  • Apolipoproteins B (metabolism)
  • Atorvastatin
  • Carrier Proteins (genetics)
  • Dose-Response Relationship, Drug
  • Female
  • Heptanoic Acids (administration & dosage, pharmacology)
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors (administration & dosage, pharmacology)
  • Hyperlipidemia, Familial Combined (drug therapy, genetics)
  • Lipoproteins (blood)
  • Male
  • Middle Aged
  • Pilot Projects
  • Polymorphism, Genetic
  • Postprandial Period
  • Pyrroles (administration & dosage, pharmacology)
  • Triglycerides (blood)

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