Abstract | OBJECTIVE: METHODS: A cross-sectional survey of patients with IBD who were treated with anti-TNF agents was performed. Results of the validated HRQoL measures ( inflammatory bowel disease questionnaire [IBDQ], EuroQoL-5 dimensions [EQ-5D], health status visual analogue scale [VAS] and the Zung self-rating depression scale) were recorded and compared between patients treated with anti-TNF agents for <1 year and ≥1 year. RESULTS: A total of 41 patients were finally enrolled in the study. Among them, 11 (26.8%) had received anti-TNF therapy for less than one year with a median duration of 7 months (range 3-11 months), while the other 30 (73.2%) had been treated for ≥1 year with a median duration of 42 months (range 12-104 months). Crohn's disease was the most common type in both groups. None of the mean IBDQ, EQ-5D and EQ-5D plus VAS, or Zung self-rating depression scale scores differed significantly between the two groups of patients. CONCLUSIONS: Improvements in HRQoL for IBD patients on anti-TNF therapy were sustained for longer than one year. HRQoL measures for IBD patients treated with anti-TNF therapy for <1 year do not differ significantly from those treated for ≥1 year, but a trend towards improved HRQoL measures with prolonged therapy can be obtained.
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Authors | Michael Sherman, Donald N Tsynman, Albert Kim, Jyoti Arora, Timothy Pietras, Susan Messing, Lydia St Hilaire, Sonia Yoon, Arthur Decross, Ashok Shah, Lawrence Saubermann |
Journal | Journal of digestive diseases
(J Dig Dis)
Vol. 15
Issue 4
Pg. 174-9
(Apr 2014)
ISSN: 1751-2980 [Electronic] Australia |
PMID | 24373601
(Publication Type: Journal Article)
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Copyright | © 2013 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd. |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Gastrointestinal Agents
- Immunosuppressive Agents
- Tumor Necrosis Factor-alpha
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Topics |
- Adult
- Aged
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, therapeutic use)
- Cross-Sectional Studies
- Drug Administration Schedule
- Drug Evaluation
(methods)
- Female
- Gastrointestinal Agents
(administration & dosage, therapeutic use)
- Health Status Indicators
- Humans
- Immunosuppressive Agents
(administration & dosage, therapeutic use)
- Inflammatory Bowel Diseases
(drug therapy, rehabilitation)
- Male
- Middle Aged
- Psychometrics
- Quality of Life
- Time Factors
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
- Young Adult
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