Cell populations in pagetoid reticulosis: an immunological study using cell activation associated monoclonal antibodies.

Abstract

The nature of the epidermal cellular infiltrate in pagetoid reticulosis is still subject to intense controversies. Using a panel of recently developed monoclonal antibodies against cell activation and proliferation associated antigens it was possible to demonstrate the activated state of numerous T cells within the lesional epidermis. Moreover approximately 10% of these T cells reacted with proliferation associated antigens. In addition macrophages and Langerhans' cells were found to represent a regular constituent of the epidermal infiltrate with a density clearly exceeding that of unaffected adjacent epidermis. The close apposition of activated T cells and monocytic cells suggests an intensive interaction of both cell types in the development of the pagetoid reticulosis lesion.

• Authors: P Kaudewitz, G Burg, G Majiewski, J Gerdes, R Schwarting, O Braun-Falco
• Journal: Acta dermato-venereologica (Acta Derm Venereol) Vol. 67 Issue 1 Pg. 24-9 ( 1987) ISSN: 0001-5555 [Print] Sweden
• PMID: 2436410 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal

Topics

• Adult
• Antibodies, Monoclonal
• Biopsy
• Female
• Humans
• Langerhans Cells (pathology)
• Lymphatic Diseases (pathology)
• Macrophages (pathology)
• Male
• Middle Aged
• Skin (pathology)
• Skin Neoplasms (pathology)
• T-Lymphocytes (classification)