Adenosine 5'-triphosphate (ATP) inhibits schwann cell demyelination during Wallerian degeneration.

Abstract

Adenosine 5'-triphosphate (ATP) is implicated in intercellular communication as a neurotransmitter in the peripheral nervous system. In addition, ATP is known as lysosomal exocytosis activator. In this study, we investigated the role of extracellular ATP on demyelination during Wallerian degeneration (WD) using ex vivo and in vivo nerve degeneration models. We found that extracellular ATP inhibited myelin fragmentation and axonal degradation during WD. Furthermore, metformin and chlorpromazine, lysosomal exocytosis antagonists blocked the effect of ATP on the inhibition of demyelination. Thus, these findings indicate that ATP-induced-lysosomal exocytosis may be involved in demyelination during WD.

• Authors: Youn Ho Shin, Hyung-Joo Chung, Chan Park, Junyang Jung, Na Young Jeong
• Journal: Cellular and molecular neurobiology (Cell Mol Neurobiol) Vol. 34 Issue 3 Pg. 361-8 (Apr 2014) ISSN: 1573-6830 [Electronic] United States
• PMID: 24363123 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adenosine Triphosphate

Topics

• Adenosine Triphosphate (pharmacology, therapeutic use)
• Animals
• Cells, Cultured
• Demyelinating Diseases (pathology, prevention & control)
• Male
• Mice
• Mice, Inbred C57BL
• Organ Culture Techniques
• Schwann Cells (drug effects, pathology)
• Wallerian Degeneration (drug therapy, pathology)