Abstract |
Antidepressants can increase the spontaneous risk of hypomania or mania when used for treatment in affective disorders. When prescribed as an antidepressant, bupropion is generally considered to have a lower relative risk of inducing mood shifts. We describe the case of a 67-year-old man known for dysthymic disorder in remission on quetiapine and venlafaxine who experienced a first lifetime episode of hypomania with the introduction of bupropion SR for smoking cessation. To the best of our knowledge, this is the first case report of bupropion-induced mood shift when used specifically for nicotine cessation in a nonbipolar patient. This case highlights the need for clinicians who prescribe bupropion for smoking cessation to perform regular and systematic mood follow-ups during treatment. These follow-ups could even be more important when bupropion is selected to quit smoking in a patient already taking an antidepressant.
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Authors | Karine Giasson-Gariépy, Didier Jutras-Aswad |
Journal | Addiction science & clinical practice
(Addict Sci Clin Pract)
Vol. 8
Pg. 22
(Dec 21 2013)
ISSN: 1940-0640 [Electronic] England |
PMID | 24359680
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidepressive Agents, Second-Generation
- Bupropion
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Topics |
- Aged
- Antidepressive Agents, Second-Generation
(administration & dosage, therapeutic use)
- Bipolar Disorder
(chemically induced)
- Bupropion
(adverse effects, therapeutic use)
- Dysthymic Disorder
(complications)
- Humans
- Male
- Smoking Cessation
(methods)
- Substance Withdrawal Syndrome
(complications, drug therapy)
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