HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

External validation of nomogram predicting the probability of specimen-confined disease (pT2-3a, R0N0) in patients undergoing radical prostatectomy and pelvic lymph node dissection.

AbstractINTRODUCTION:
Before radical prostatectomy (RP), a nomogram [Briganti et al., Eur Urol 2012;61:584-592] permits to measure the probability of specimen-confined (SC) disease (pT2-pT3a, node negative with negative margins) in high-risk prostate cancer (PCa). The aim of our study was to perform an external validation of this nomogram.
MATERIALS AND METHODS:
Between 2007 and 2011, 623 patients with high-risk PCa (prostate-specific antigen (PSA) >20 ng/ml and/or biopsy Gleason score ≥8 and/or clinical stage T3) underwent RP and pelvic lymph node dissection at tertiary referral centers. Multivariable logistic regression models predicting the presence of SC disease were built in; we then used the area under curve of the receiver operating characteristic analysis to quantify accuracy of the nomogram to predict SC disease. The extent of over- or underestimation was evaluated within calibration plots.
RESULTS:
29% (181/623) of men had SC disease at RP. Preoperative PSA, biopsy Gleason score and stage differed significantly (all p < 0.001) between men with SC disease and those without. External validation of the nomogram showed an acceptable accuracy (area under curve: 66.3, 95% CI 62.4-70%) and a perfect calibration plot.
CONCLUSIONS:
The external cohort validates the original nomogram, with perfect calibration characteristics. The adequate although reduced accuracy may reflect the wide spectrum and behavior of the so-called high-risk PCa.
AuthorsLuigi Mearini, Mauro Gacci, Omar Saleh, Cosimo De Nunzio, Riccardo Schiavina, Alchiede Simonato, Andrea Tubaro, Giorgio Carmignani, Vincenzo Mirone, Marco Carini, Vittorio Bini, Massimo Porena, Multicenter Italian Report on Radical Prostatectomy: Outcome and Research (MIRROR) Project-Leading Urological No-Profit Foundation for Advanced Research (LUNA) Foundation
JournalUrologia internationalis (Urol Int) Vol. 93 Issue 3 Pg. 262-8 ( 2014) ISSN: 1423-0399 [Electronic] Switzerland
PMID24356093 (Publication Type: Journal Article)
Copyright2013 S. Karger AG, Basel.
Chemical References
  • Prostate-Specific Antigen
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Calibration
  • Cohort Studies
  • Humans
  • Lymph Node Excision (methods)
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Nomograms
  • Probability
  • Prostate-Specific Antigen (metabolism)
  • Prostatectomy (methods)
  • Prostatic Neoplasms (diagnosis, surgery)
  • ROC Curve
  • Regression Analysis
  • Reproducibility of Results
  • Risk Factors
  • Sensitivity and Specificity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: