Paxillin and carbonic anhydrase IX are prognostic markers in gallbladder squamous cell/adenosquamous carcinomas and adenocarcinomas.

Abstract

AIMS:

Squamous cell/adenosquamous carcinomas (SC/ASC) are rare subtypes of gallbladder cancers (GBCs). Clinical characteristics of SC/ASC have not been well documented, and no biological markers of GBC carcinogenesis, progression and prognosis are available.

METHODS AND RESULTS:

We measured paxillin and CAIX expression in 46 SC/ASCs and 80 adenocarcinomas (ACs) with immunohistochemistry and correlated these data with clinicopathological characteristics. Both paxillin expression and CAIX expression were associated significantly with larger tumours, a higher tumour-node-metastasis (TNM) stage, lymph node metastasis and invasiveness of SC/ASC and AC. Univariate Kaplan-Meier analysis confirmed that paxillin and CAIX expression were associated closely with decreased overall survival in SC/ASC (both P < 0.001) and AC (both P < 0.001). Multivariate Cox regression analysis confirmed that paxillin expression and CAIX expression both independently predicted poor prognosis in SC/ASC and AC patients. We also noted correlations with survival and tumour differentiation, tumour size, TNM stage, lymph node metastasis, tumour invasiveness and sample procurement methods.

CONCLUSIONS:

Paxillin expression and CAIX expression are both related to clinical/biological behaviour and poor prognosis of GBC.

• Authors: Ziru Liu, Zhulin Yang, Song Jiang, Qiong Zou, Yuan Yuan, Jinghe Li, Daiqiang Li, Lufeng Liang, Meigui Chen, Senlin Chen
• Journal: Histopathology (Histopathology) Vol. 64 Issue 7 Pg. 921-34 (Jun 2014) ISSN: 1365-2559 [Electronic] England
• PMID: 24354963 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 John Wiley & Sons Ltd.

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• PXN protein, human
• Paxillin
• CA9 protein, human
• Carbonic Anhydrase IX
• Carbonic Anhydrases

Topics

• Adenocarcinoma (metabolism, pathology)
• Adult
• Aged
• Aged, 80 and over
• Antigens, Neoplasm (metabolism)
• Biomarkers, Tumor (metabolism)
• Carbonic Anhydrase IX
• Carbonic Anhydrases (metabolism)
• Carcinoma, Adenosquamous (metabolism, pathology)
• Carcinoma, Squamous Cell (metabolism, pathology)
• Female
• Gallbladder Neoplasms (metabolism, pathology)
• Humans
• Male
• Middle Aged
• Paxillin (metabolism)
• Prognosis