High mitochondrial accumulation of new gadolinium(III) agents within tumour cells.

Abstract

The first bifunctional Gd(III) complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 10(10) Gd atoms per tumour cell.

• Authors: Daniel E Morrison, Jade B Aitken, Martin D de Jonge, Joseph A Ioppolo, Hugh H Harris, Louis M Rendina
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 50 Issue 18 Pg. 2252-4 (Mar 04 2014) ISSN: 1364-548X [Electronic] England
• PMID: 24352097 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Organometallic Compounds
• Gadolinium

Topics

• Antineoplastic Agents (chemistry, metabolism, pharmacology)
• Cell Line, Tumor
• Dose-Response Relationship, Drug
• Drug Design
• Drug Screening Assays, Antitumor
• Gadolinium (chemistry, metabolism, pharmacology)
• Humans
• Mitochondria (chemistry, drug effects, metabolism)
• Molecular Structure
• Neoplasms (drug therapy, metabolism, pathology)
• Organometallic Compounds (chemistry, metabolism, pharmacology)
• Structure-Activity Relationship