[Immunohistochemical study of placental alkaline phosphatase in seminoma].

Abstract

Indirect immunoperoxidase staining was carried out on seminomatous tumors of testes (22 specimens) using anti-placental alkaline phosphatase antibody to search for the usefulness of placental alkaline phosphatase as a tumor marker. All of the seminomas showed positive staining mainly on the cell surface. However, the normal testes and non-seminomas showed negative staining. Of interest, normal tissues outside the tumor mass showed positive staining. This phenomenon is considered to be suggestive of carcinoma in situ. Immunohistochemical study of placental alkaline phosphatase on the seminomas is a useful method for histopathological diagnosis and may be useful for understanding the pathogenesis of the tumor.

• Authors: M Shiramizu, H Hoshino, Y Katsuoka, Y Osamura
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 32 Issue 12 Pg. 1843-8 (Dec 1986) ISSN: 0018-1994 [Print] Japan
• PMID: 2435133 (Publication Type: English Abstract, Journal Article)

Chemical References

• GPI-Linked Proteins
• Isoenzymes
• Alkaline Phosphatase
• alkaline phosphatase, placental

Topics

• Alkaline Phosphatase
• Dysgerminoma (diagnosis)
• GPI-Linked Proteins
• Histocytochemistry
• Humans
• Immunoenzyme Techniques
• Isoenzymes (analysis)
• Male
• Staining and Labeling
• Testicular Neoplasms (diagnosis)