Abstract | BACKGROUND: MATERIAL AND METHOD: Eighty-six patients participated in this randomized controlled trial. They were assigned into either the benzydamine hydrochloride or the control group. The whole ETT cuff was dripped either with 3 ml (4.5 mg) of benzydamine hydrochloride or nothing five minutes prior to anesthesia induction. The incidence and severity of POST at 0, 2, 4, 6, 12 and 24 hours postoperatively were assessed. The potential adverse effects of benzydamine hydrochloride (throat numbness throat burning sensation, dry mouth, and thirst) were also evaluated. RESULTS: Twenty-five patients (58.14%) in each group had POST (p-value = 1). The severity of POST (calculated from affected patients) in both groups at different time points was not significantly different. Patients in the benzydamine hydrochloride group did not have a higher incidence of adverse effects. CONCLUSION: We found that dripping benzydamine hydrochloride on the ETT cuff neither reduced the incidence of POST nor increased the incidence of adverse effects in comparison with no intervention.
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Authors | Sasikaan Nimmaanrat, Kedsirin Chokkijchai, Thavat Chanchayanon |
Journal | Journal of the Medical Association of Thailand = Chotmaihet thangphaet
(J Med Assoc Thai)
Vol. 96
Issue 10
Pg. 1331-7
(Oct 2013)
ISSN: 0125-2208 [Print] Thailand |
PMID | 24350416
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents
- Benzydamine
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Topics |
- Adult
- Anti-Inflammatory Agents
(administration & dosage, therapeutic use)
- Benzydamine
(administration & dosage, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Intubation, Intratracheal
(adverse effects)
- Male
- Pharyngitis
(prevention & control)
- Postoperative Complications
(prevention & control)
- Prospective Studies
- Treatment Outcome
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