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Poly-cyclodextrin functionalized porous bioceramics for local chemotherapy and anticancer bone reconstruction.

Abstract
The progress in bone cancer surgery and multimodal treatment concept achieve only modest improvement in the overall survival, due to failure in clearing out residual cancer cells at the surgical margin and extreme side-effects of adjuvant postoperative treatments. Our study aims to propose a new method based on cyclodextrin polymer (polyCD) functionalized hydroxyapatite (HA) for achieving a high local drug concentration with a sustained release profile and a better control of residual malignant cells via local drug delivery and promotion of the reconstruction of bone defects. PolyCD, a versatile carrier for therapeutic molecules, can be incorporated into HA (bone regeneration scaffold) through thermal treatment. The parameters of polyCD treatment on the macroporous HA (porosity 65%) were characterized via thermogravimetric analysis. Good cytocompatibility of polyCD functionalized bioceramics was demonstrated on osteoblast cells by cell vitality assay. An antibiotic (gentamicin) and an anticancer agent (cisplatin) were respectively loaded on polyCD functionalized bioceramics for drug release test. The results show that polyCD functionalization leads to significantly improved drug loading quantity (30% more concerning gentamicin and twice more for cisplatin) and drug release duration (7 days longer concerning gentamicin and 3 days longer for cisplatin). Conclusively, this study offers a safe and reliable drug delivery system for bioceramic matrices, which can load anticancer agents (or/and antibiotics) to reduce local recurrence (or/and infection).
AuthorsFeng Chai, Mohamed Abdelkarim, Thomas Laurent, Nicolas Tabary, Stephanie Degoutin, Nicolas Simon, Fabian Peters, Nicolas Blanchemain, Bernard Martel, Hartmut F Hildebrand
JournalJournal of biomedical materials research. Part B, Applied biomaterials (J Biomed Mater Res B Appl Biomater) Vol. 102 Issue 6 Pg. 1130-9 (Aug 2014) ISSN: 1552-4981 [Electronic] United States
PMID24347296 (Publication Type: Journal Article)
Copyright© 2014 Wiley Periodicals, Inc.
Chemical References
  • Bone Substitutes
  • Cyclodextrins
  • Polymers
  • Durapatite
Topics
  • Animals
  • Bone Neoplasms (therapy)
  • Bone Substitutes (chemistry, pharmacology)
  • Cell Line
  • Ceramics (chemistry, pharmacokinetics)
  • Cyclodextrins (chemistry, pharmacology)
  • Drug Delivery Systems
  • Durapatite (chemistry, pharmacology)
  • Materials Testing (methods)
  • Mice
  • Osteoblasts (metabolism, pathology)
  • Polymers (chemistry, pharmacology)
  • Porosity
  • Tissue Scaffolds

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