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Mental disturbances in Parkinson's disease and related disorders: the role of excitotoxins.

Abstract
The pathomechanism behind the neurodegenerative process in Parkinson's disease involves damage to the dopaminergic and nondopaminergic systems with dysfunctioning of the dopaminergic-glutamatergic circuitry in the basal ganglional neural processing. Excitotoxicity may contribute markedly to neuronal damage and loss. Beside the cardinal motor signs of the disease, non-motor symptoms, including mental disturbances, are characteristic features of the clinical course. Affective or autonomic changes may precede motor symptoms. Neuroprotective drugs are not yet available. However, new modes of therapy targeting the defective dopaminergic-glutamatergic system might also be effective both for symptomatologic treatment and for neuroprotection. Alterations in the kynurenine pathway have been demonstrated in Parkinson's disease. Preclinical studies suggest that intervention in the kynurenine pathway may result in neuroprotection and additionally alleviate the symptoms through influencing the glutamatergic neurotransmission.
AuthorsIzabella Obál, Zsófia Majláth, József Toldi, László Vécsei
JournalJournal of Parkinson's disease (J Parkinsons Dis) Vol. 4 Issue 2 Pg. 139-50 ( 2014) ISSN: 1877-718X [Electronic] Netherlands
PMID24346238 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Neuroprotective Agents
  • Neurotoxins
  • Kynurenine
  • Glutamic Acid
  • Dopamine
Topics
  • Dopamine (metabolism)
  • Glutamic Acid (metabolism)
  • Humans
  • Kynurenine (metabolism)
  • Mental Disorders (drug therapy, etiology, metabolism)
  • Neuroprotective Agents (therapeutic use)
  • Neurotoxins (metabolism)
  • Parkinson Disease (complications, metabolism)

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