Abstract | OBJECTIVE: STUDY DESIGN: Randomized, blinded, prospective clinical study. ANIMALS: Twenty-six dogs admitted for elective soft tissue or orthopedic procedures that were 3.1 ±3.1 years of age and weighed 20.5 ± 11.4 kg. METHODS: Dogs were randomly assigned to one of two groups: Group M received maropitant (1.0 mg kg(-1) ) and Group S received 0.9% saline (0.1 mL kg(-1) ) intravenously 45-60 minutes before premedication with hydromorphone (0.1 mg kg(-1) ) and acepromazine (0.03 mg kg(-1) ) intramuscularly. An observer blinded to treatment documented any retching or vomiting for 20 minutes before induction with propofol (2-6 mg kg(-1) ) and inhalation anesthesia. A pH probe inserted into the distal esophagus was used to detect GER. RESULTS: None of the dogs in Group M retched or vomited (0/13), 6/13 (46%) in Group S were observed to retch or vomit, and the difference between groups was significant (p = 0.015). There were no differences between groups in the number of dogs with GER (Group M: 4/13, Group S: 6/13 dogs) or the number of reflux events. Esophageal pH at the end of anesthesia was significantly lower in both M and S groups in dogs with GER versus dogs without GER (p = 0.004 and 0.011, respectively). Only dogs with GER in Group S had significantly lower pH at the end compared to the beginning of anesthesia (p = 0.004). CONCLUSIONS AND CLINICAL RELEVANCE:
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Authors | Rebecca A Johnson |
Journal | Veterinary anaesthesia and analgesia
(Vet Anaesth Analg)
Vol. 41
Issue 4
Pg. 406-10
(Jul 2014)
ISSN: 1467-2995 [Electronic] United States |
PMID | 24330310
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia. |
Chemical References |
- Analgesics, Opioid
- Antiemetics
- Dopamine Antagonists
- Quinuclidines
- maropitant
- Acepromazine
- Hydromorphone
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Topics |
- Acepromazine
(administration & dosage, adverse effects)
- Analgesics, Opioid
(administration & dosage, adverse effects)
- Anesthesia, Inhalation
(adverse effects, veterinary)
- Animals
- Antiemetics
(administration & dosage, pharmacology)
- Dog Diseases
(chemically induced, prevention & control)
- Dogs
- Dopamine Antagonists
(administration & dosage, adverse effects)
- Esophagus
- Female
- Gastroesophageal Reflux
(chemically induced, prevention & control, veterinary)
- Hydrogen-Ion Concentration
- Hydromorphone
(administration & dosage, adverse effects)
- Male
- Quinuclidines
(administration & dosage, pharmacology)
- Vomiting
(chemically induced, prevention & control, veterinary)
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