Pharmacogenetics and individualizing drug treatment during pregnancy.

Abstract

Pharmacogenetics as a tool to aid clinicians implement individualized pharmacotherapy is utilized in some areas of medicine. Pharmacogenetics in pregnancy is still a developing field. However, there are several areas of obstetric therapeutics where data are emerging that give glimpses into future therapeutic possibilities. These include opioid pain management, antihypertensive therapy, antidepressant medications, preterm labor tocolytics, antenatal corticosteroids and drugs for nausea and vomiting of pregnancy, to name a few. More data are needed to populate the therapeutic models and to truly determine if pharmacogenetics will aid in individualizing pharmacotherapy in pregnancy. The objective of this review is to summarize current data and highlight research needs.

• Authors: David M Haas
• Journal: Pharmacogenomics (Pharmacogenomics) Vol. 15 Issue 1 Pg. 69-78 (Jan 2014) ISSN: 1744-8042 [Electronic] England
• PMID: 24329192 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Antidepressive Agents
• Antihypertensive Agents
• Tocolytic Agents

Topics

• Antidepressive Agents (adverse effects)
• Antihypertensive Agents (adverse effects)
• Female
• Humans
• Infant, Newborn
• Pain Management (adverse effects)
• Pharmacogenetics
• Precision Medicine
• Pregnancy
• Pregnancy Complications (chemically induced, pathology)
• Tocolytic Agents (adverse effects)