Oncologic results of the surgical salvage of recurrent laryngeal squamous cell carcinoma in a multicentric retrospective series: emerging role of supracricoid partial laryngectomy.

Abstract

BACKGROUND:

Several studies in the last decade evaluated conservative surgical procedures and, in particular, supracricoid operations as an alternative to total laryngectomy for the salvage of recurrences of laryngeal squamous cell carcinoma (SCC) after a first attempt of organ preservation.

METHODS:

The clinical records of 68 consecutive patients primarily treated by irradiation or endoscopic surgery and surgically salvaged by total laryngectomy or supracricoid partial laryngectomy in 2 large university hospitals in Italy from 2004 to 2010 were reviewed.

RESULTS:

The survival was not affected by the primary treatment or by salvage modality. The only parameter always keeping a prognostic value is the involvement of resection margins of salvage surgery. Patients with early relapse seem to have a worse prognosis than patients with a delayed relapse (p = .05 at Cox multivariate analysis and p = .048 at Wilcoxon test for overall survival [OS] from the primary treatment).

CONCLUSION:

Supracricoid operations, if the indications are careful, can prove reliable salvage procedures.

• Authors: Marco de Vincentiis, Armando De Virgilio, Francesco Bussu, Roberto Gallus, Andrea Gallo, Giovanni Bastanza, Claudio Parrilla, Antonio Greco, Jacopo Galli, Rosaria Turchetta, Giovanni Almadori, Giulio Pagliuca, Vincenzo Valentini, Gaetano Paludetti
• Journal: Head & neck (Head Neck) Vol. 37 Issue 1 Pg. 84-91 (Jan 2015) ISSN: 1097-0347 [Electronic] United States
• PMID: 24327466 (Publication Type: Journal Article, Multicenter Study)
• Copyright: © 2014 Wiley Periodicals, Inc.

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Squamous Cell (mortality, pathology, therapy)
• Cricoid Cartilage
• Female
• Humans
• Italy
• Laryngeal Neoplasms (mortality, pathology, therapy)
• Laryngectomy (methods)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (mortality, pathology, therapy)
• Retrospective Studies
• Salvage Therapy
• Survival Rate
• Treatment Outcome