Abstract |
New therapies are needed to improve current results in diffuse intrinsic pontine glioma. We present here the initial experience of administering Celyvir, autologous mesenchymal stem cells infected with ICOVIR-5, an oncolytic adenovirus that selectively replicates in cancer cells, by means of superselective intra-arterial delivery, in a patient diagnosed of diffuse intrinsic pontine glioma. Feasibility, safety, and morbidity rates of the superselective catheterization technique are comparable with those of diagnostic angiography. The intra-arterial approach warrants a greater contact of the mesenchymal stem cells with the tumor mass, and minimizes hemorrhages or vascular disruption. The tolerance to the 2 administrations was excellent, with no acute or delayed adverse effect, underscoring the feasibility of this technique for the delivery of virotherapies and/or cellular therapies in this location.
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Authors | Fernando Carceller, Aitziber Aleu, Alfredo Casasco, Leopoldo Guimaraens, Migel A López-Pino, Luís Madero, Manuel Ramírez |
Journal | Journal of pediatric hematology/oncology
(J Pediatr Hematol Oncol)
Vol. 36
Issue 7
Pg. e430-2
(Oct 2014)
ISSN: 1536-3678 [Electronic] United States |
PMID | 24327128
(Publication Type: Case Reports, Journal Article)
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Topics |
- Brain Stem Neoplasms
(pathology, therapy)
- Catheterization
(methods)
- Child
- Fatal Outcome
- Female
- Glioma
(pathology, therapy)
- Humans
- Infusions, Intra-Arterial
(methods)
- Mesenchymal Stem Cell Transplantation
(methods)
- Oncolytic Virotherapy
(methods)
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