Abstract | INTRODUCTION:
Male breast carcinoma is a rare condition, but with a trend of increase frequency. In our study, we investigate the clinico-pathological features and overall survival at 35 male cases of primary invasive breast carcinoma correlated with molecular subtypes defined by immunohistochemical profile. METHODS: RESULTS: In our study, we identified 65.7% as Luminal A subtype and 28.6% as Luminal B subtype. The difference was represented by two (5.7%) cases of triple negative subtype, but due to low number of patients, no correlations or prognostic significance could be assessed in these cases. No HER2 or unclassified subtypes were identified. CONCLUSIONS:
Luminal A tumors are the most frequent subtype in MBC, with a better outcome than Luminal B subtype. We recorded high levels of ER and PR expression, which predict a better response to adjuvant hormonal therapy. At the time of diagnosis, most of the patients were aged and with an advance clinical stage, this requiring implementation of screening programs and increase education of population in order to an early detection.
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Authors | Mariana Aşchie, Gabriela Izabela Bălţătescu, Anca Mitroi |
Journal | Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
(Rom J Morphol Embryol)
Vol. 54
Issue 3 Suppl
Pg. 749-55
( 2013)
ISSN: 2066-8279 [Electronic] Romania |
PMID | 24322022
(Publication Type: Journal Article)
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Chemical References |
- Tumor Suppressor Protein p53
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms, Male
(classification, metabolism, pathology)
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Neoplasm Invasiveness
- Tumor Suppressor Protein p53
(metabolism)
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