In vivo analysis of antioxidant and prooxidant properties of retinol acetate.

Analysis of the effects of retinol acetate on LPO processes in vivo revealed antioxidant effects under normal conditions and during experimental free-radical pathology (toxic hepatosis-hepatitis). The concentration inversion of antioxidant effects of retinol acetate into prooxidant effects were observed only under normal conditions.
AuthorsS K Pravkin, E N Yakusheva, D G Uzbekova
JournalBulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 156 Issue 2 Pg. 220-3 (Dec 2013) ISSN: 1573-8221 [Electronic] United States
PMID24319753 (Publication Type: Journal Article)
Chemical References
  • Antioxidants
  • Free Radicals
  • Lipid Peroxides
  • Reactive Oxygen Species
  • Vitamin A
  • retinol acetate
  • Malondialdehyde
  • Glutathione Peroxidase
  • Glutathione Transferase
  • Animals
  • Antioxidants (administration & dosage)
  • Disease Models, Animal
  • Free Radicals (metabolism)
  • Glutathione Peroxidase (biosynthesis, metabolism)
  • Glutathione Transferase (biosynthesis, metabolism)
  • Hepatitis (drug therapy, metabolism)
  • Lipid Peroxides (metabolism)
  • Male
  • Malondialdehyde (analysis)
  • Rats
  • Reactive Oxygen Species (metabolism)
  • Vitamin A (administration & dosage, analogs & derivatives, blood)

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